Desmethylsibutramine

Desmethylsibutramine is a pharmacological compound that is primarily recognized as the primary active metabolite of the anti-obesity medication sibutramine. It is a centrally-acting serotonin-norepinephrine reuptake inhibitor (SNRI) that is used in the treatment of obesity.

Pharmacology[edit | edit source]

Desmethylsibutramine is a potent inhibitor of serotonin and norepinephrine reuptake, which leads to increased levels of these neurotransmitters in the synaptic cleft. This results in increased satiety and decreased food intake, thereby aiding in weight loss. It is also a weak inhibitor of dopamine reuptake.

Clinical Use[edit | edit source]

Desmethylsibutramine is not used clinically on its own, but is the primary active metabolite of sibutramine. Sibutramine was used as an anti-obesity medication until it was withdrawn from the market due to concerns about cardiovascular side effects.

Side Effects[edit | edit source]

The side effects of desmethylsibutramine are similar to those of sibutramine and include dry mouth, constipation, insomnia, and increased heart rate. More serious side effects can include high blood pressure and increased risk of cardiovascular events.