Diacetyldihydromorphine

Diacetyldihydromorphine is a semi-synthetic opioid derived from morphine. It is also known by its brand name, Paralaudin. It is a potent analgesic, used primarily in the treatment of severe pain.

Chemistry

Diacetyldihydromorphine is a morphine derivative where the 3 and 6 hydroxyl groups have been acetylated. It is chemically similar to heroin, which is also a diacetylated morphine derivative, but has a different effect profile due to its different metabolic pathway.

Pharmacology

Diacetyldihydromorphine acts primarily on the mu-opioid receptor, but also has effects on the delta and kappa opioid receptors. It has a high affinity for the mu receptor, which is responsible for its potent analgesic effects. It is metabolized in the liver by esterases to 6-acetyldihydromorphine and dihydromorphine, both of which are also active opioids.

Clinical Use

Diacetyldihydromorphine is used in the treatment of severe pain, such as that caused by cancer or severe injury. It is typically administered via injection, but can also be taken orally. Due to its potency and potential for addiction, it is a controlled substance in many countries.

Side Effects

Common side effects of diacetyldihydromorphine include nausea, vomiting, constipation, and drowsiness. Like other opioids, it also carries a risk of addiction and dependence. Overdose can lead to respiratory depression and death.

See Also

• Morphine
• Heroin
• Opioid receptor
• Esterases