Diacylglycerol O-acyltransferase 2

Diacylglycerol O-acyltransferase 2 (DGAT2) is an enzyme that in humans is encoded by the DGAT2 gene. DGAT2 is one of two known DGATs that catalyze the final step in the synthesis of triglycerides, the primary storage form of lipids in the body.

Function

DGAT2 is a membrane-bound enzyme that is localized in the endoplasmic reticulum, the site of lipid synthesis within cells. It catalyzes the formation of triglycerides from diacylglycerol and Acyl-CoA, a reaction that is the final and only committed step in the synthesis of triglycerides.

Clinical significance

Mutations in the DGAT2 gene have been associated with a number of metabolic disorders, including obesity, insulin resistance, and non-alcoholic fatty liver disease. Inhibition of DGAT2 has been proposed as a potential therapeutic strategy for these conditions.

See also

• Diacylglycerol O-acyltransferase
• Triglyceride
• Lipid metabolism

External links

• GeneCards - DGAT2