Dihydropicrotoxinin

Dihydropicrotoxinin is a chemical compound that is a derivative of picrotoxin, a naturally occurring substance found in the fruit of the Anamirta cocculus plant. It is a potent neurotoxin that acts as a non-competitive antagonist at the GABA receptor, blocking the action of the neurotransmitter GABA and leading to convulsions and death in high doses.

Chemical Structure

Dihydropicrotoxinin is a sesquiterpene that is structurally similar to picrotoxinin, the active component of picrotoxin. It has a seven-membered ring with two additional rings attached, and contains several oxygen and hydroxyl groups.

Pharmacology

Dihydropicrotoxinin acts as a non-competitive antagonist at the GABA receptor, meaning it binds to a site on the receptor that is distinct from the GABA binding site and inhibits the action of GABA. This leads to an increase in neuronal excitability, which can result in convulsions and death in high doses.

Toxicity

The toxicity of dihydropicrotoxinin is similar to that of picrotoxin. It is a potent neurotoxin that can cause convulsions and death in high doses. Symptoms of poisoning include restlessness, tremors, convulsions, and respiratory failure.

See Also

• Picrotoxin
• GABA receptor
• Neurotoxin

Dihydropicrotoxinin Resources
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