Dihydroxyphenylethylene glycol

Dihydroxyphenylethylene glycol (DOPEG) is a metabolite of the neurotransmitter norepinephrine. It is produced in the body through the action of the enzyme monoamine oxidase (MAO), which breaks down norepinephrine, releasing DOPEG as a byproduct.

Chemical Structure and Properties

DOPEG is a phenolic compound, meaning it contains a benzene ring with one or more hydroxyl groups attached. Its chemical formula is C8H11NO3. It is a colorless, crystalline solid that is soluble in water and alcohol.

Biological Role

In the human body, DOPEG serves as an indicator of norepinephrine activity. High levels of DOPEG in the urine or blood can indicate increased norepinephrine release, which may be associated with certain medical conditions such as pheochromocytoma, a rare tumor of the adrenal gland.

Clinical Significance

Measurement of DOPEG levels can be used in the diagnosis and monitoring of pheochromocytoma. In addition, elevated DOPEG levels have been observed in patients with Parkinson's disease, suggesting a role for norepinephrine dysfunction in this condition.

Research

Research into the role of DOPEG and other norepinephrine metabolites in neurological and psychiatric disorders is ongoing. Understanding the pathways of norepinephrine metabolism and the effects of its metabolites could lead to new treatments for conditions such as depression, anxiety, and Parkinson's disease.

See Also

• Norepinephrine
• Monoamine oxidase
• Pheochromocytoma
• Parkinson's disease