Dipeptidase 2

Dipeptidase 2 (DPEP2) is an enzyme that is encoded by the DPEP2 gene in humans. This enzyme is part of the dipeptidase family, which is responsible for the hydrolysis of dipeptides into their constituent amino acids.

Function

Dipeptidase 2 is a cytosolic enzyme that is primarily expressed in the kidney and liver. It plays a crucial role in the final step of protein degradation, breaking down dipeptides for absorption or further degradation. This process is essential for the recycling of amino acids and the maintenance of protein homeostasis in the body.

Structure

The DPEP2 gene is located on the long arm of chromosome 16 (16q24.3). The enzyme itself is a homodimer, meaning it consists of two identical subunits. Each subunit contains a zinc ion, which is necessary for the enzyme's catalytic activity.

Clinical significance

Alterations in the DPEP2 gene or enzyme activity have been associated with various health conditions. For example, reduced DPEP2 activity has been observed in individuals with chronic kidney disease, suggesting a potential role in kidney function. Further research is needed to fully understand the clinical implications of DPEP2.

See also

• Dipeptidase
• Dipeptidase 1
• Dipeptidase 3

References

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