Dipeptidase 3

Dipeptidase 3 (DPEP3) is an enzyme that is encoded by the DPEP3 gene in humans. This enzyme is part of the dipeptidase family, which is responsible for the hydrolysis of dipeptides. Dipeptidase 3 is specifically involved in the breakdown of dipeptides into their constituent amino acids.

Function

Dipeptidase 3 is a cytosolic enzyme that is widely expressed in various tissues, including the kidney, liver, and brain. It plays a crucial role in the final step of protein degradation, where it cleaves dipeptides into individual amino acids. This process is essential for the recycling of amino acids and the maintenance of protein homeostasis in the body.

Structure

The DPEP3 gene is located on chromosome 16 and consists of 10 exons. The encoded protein, dipeptidase 3, is a monomeric enzyme with a molecular weight of approximately 50 kDa. It contains a zinc binding site, which is essential for its catalytic activity.

Clinical significance

Alterations in the DPEP3 gene have been associated with various diseases. For instance, mutations in this gene have been linked to neurodegenerative diseases and cancer. Further research is needed to fully understand the role of dipeptidase 3 in these conditions.

See also

• Dipeptidase
• Protein degradation
• Amino acid