Diphenadione

Diphenadione is a vitamin K antagonist and an anticoagulant, which is often used as a rodenticide. It is a second-generation derivative in the family of coumarin-based anticoagulants. Diphenadione was first registered in the United States in 1953.

Mechanism of Action

Diphenadione exerts its anticoagulant properties by inhibiting the vitamin K epoxide reductase enzyme. This enzyme is responsible for the recycling of vitamin K in the body. By inhibiting this enzyme, Diphenadione disrupts the blood clotting process, leading to uncontrolled bleeding and eventual death in rodents.

Uses

Diphenadione is primarily used as a rodenticide. It is effective against a variety of rodents including rats, mice, and squirrels. It is often used in situations where first-generation anticoagulants have failed due to resistance.

Toxicity

Diphenadione is highly toxic to mammals and birds, and slightly toxic to fish and aquatic invertebrates. It is classified as a Category C, possible human carcinogen. Exposure to Diphenadione can lead to a variety of symptoms including nausea, vomiting, abdominal pain, and bleeding.

Treatment

Treatment for Diphenadione poisoning involves discontinuing exposure to the substance and administering vitamin K1 therapy. In severe cases, blood transfusion may be necessary.

See Also

• Anticoagulant
• Rodenticide
• Vitamin K antagonist