Dolichyl-phosphate beta-glucosyltransferase
| Dolichyl-phosphate beta-glucosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.117 | ||||||||
| CAS number | 62213-38-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Dolichyl-phosphate beta-glucosyltransferase is an enzyme that plays a crucial role in the process of glycosylation, specifically in the synthesis of glycoproteins. This enzyme is responsible for transferring a glucose molecule from UDP-glucose to dolichyl phosphate, forming dolichyl-phosphate-glucose.
Function[edit | edit source]
Dolichyl-phosphate beta-glucosyltransferase is involved in the N-linked glycosylation pathway, which is essential for the proper folding and stability of many proteins. The enzyme catalyzes the following reaction:
- UDP-glucose + dolichyl phosphate → UDP + dolichyl-phosphate-glucose
This reaction is a key step in the assembly of the dolichol-linked oligosaccharide precursor, which is subsequently transferred to nascent proteins in the endoplasmic reticulum.
Structure[edit | edit source]
The structure of dolichyl-phosphate beta-glucosyltransferase has not been fully elucidated. However, it is known to be a membrane-bound enzyme located in the endoplasmic reticulum.
Clinical Significance[edit | edit source]
Mutations or deficiencies in dolichyl-phosphate beta-glucosyltransferase can lead to disorders in glycosylation, which can result in various congenital disorders of glycosylation (CDGs). These disorders often present with a wide range of symptoms, including developmental delays, neurological issues, and other systemic problems.
Related Enzymes[edit | edit source]
Dolichyl-phosphate beta-glucosyltransferase is part of a larger family of glycosyltransferases, which are enzymes that facilitate the transfer of sugar moieties to various substrates. Other related enzymes include:
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
 | This enzyme-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
