Dual specificity phosphatase 8

Dual specificity phosphatase 8 (DUSP8) is a protein that in humans is encoded by the DUSP8 gene. This protein is a member of the dual specificity phosphatase (DUSP) subfamily of MAP kinase phosphatases, which are known to dephosphorylate critical tyrosine and threonine residues on their substrate kinases.

Function

DUSP8 is believed to regulate the activity of several MAP kinases and thus plays a role in various cellular processes such as cell growth, differentiation, and apoptosis. It is also thought to be involved in the negative regulation of cellular proliferation.

Clinical significance

Alterations in the function of DUSP8 have been associated with several diseases, including cancer, diabetes, and neurodegenerative diseases. In cancer, overexpression of DUSP8 has been observed in various types of tumors, suggesting a potential role in tumorigenesis. In diabetes, DUSP8 has been implicated in the regulation of insulin signaling and glucose homeostasis.

See also

• Dual specificity phosphatase
• Mitogen-activated protein kinase
• Protein tyrosine phosphatase

References

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