Dynein, axonemal, heavy chain 14

Dynein, Axonemal, Heavy Chain 14 (also known as DNAH14) is a protein that in humans is encoded by the DNAH14 gene. This protein is a part of the dynein family, which is a group of motor proteins that move along microtubules in cells. They convert chemical energy stored in ATP to mechanical work.

Function

DNAH14 is a heavy chain of the dynein complex. Dyneins are motor proteins that move along microtubules in cells and convert chemical energy stored in ATP to mechanical work. Dynein has several functions in the cell such as positioning the mitotic spindle during cell division, moving vesicles and organelles within the cell, and moving cilia and flagella.

Structure

The DNAH14 protein is a large protein, with a molecular weight of approximately 500 kDa. It is composed of several domains, including a motor domain that binds ATP and generates movement, and a tail domain that interacts with cargo molecules and other components of the dynein complex.

Clinical Significance

Mutations in the DNAH14 gene have been associated with primary ciliary dyskinesia, a rare genetic disorder characterized by chronic respiratory tract infections, abnormally positioned internal organs, and infertility.

See Also

• Dynein
• Microtubule
• Mitotic spindle
• Vesicle
• Organelle
• Cilia
• Flagellum
• Primary ciliary dyskinesia