E2F4

From WikiMD's Wellness Encyclopedia

E2F4 is a member of the E2F family of transcription factors. It is a key component in the regulation of the cell cycle, particularly during the G1 phase. E2F4 is known for its role in tumor suppression and its involvement in various cancer types.

Function[edit | edit source]

E2F4 is a transcription factor that forms heterodimers with proteins from the DP family of transcription factors. These heterodimers bind to the E2F response element, leading to the transcription of genes necessary for cell cycle progression. Unlike other members of the E2F family, E2F4 is typically associated with cell cycle arrest and differentiation.

Role in Cancer[edit | edit source]

E2F4 has been implicated in various types of cancer. It is often found to be overexpressed in lung cancer, breast cancer, and colorectal cancer. The overexpression of E2F4 can lead to uncontrolled cell proliferation, a hallmark of cancer. However, the exact role of E2F4 in cancer progression and its potential as a therapeutic target are still under investigation.

Clinical Significance[edit | edit source]

Due to its role in cell cycle regulation and cancer, E2F4 is a potential target for cancer therapy. Inhibiting the activity of E2F4 could potentially halt the progression of the cell cycle, thereby inhibiting tumor growth. However, more research is needed to fully understand the potential of E2F4 as a therapeutic target.

See Also[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD