E2F4

E2F4 is a member of the E2F family of transcription factors. It is a key component in the regulation of the cell cycle, particularly during the G1 phase. E2F4 is known for its role in tumor suppression and its involvement in various cancer types.

Function

E2F4 is a transcription factor that forms heterodimers with proteins from the DP family of transcription factors. These heterodimers bind to the E2F response element, leading to the transcription of genes necessary for cell cycle progression. Unlike other members of the E2F family, E2F4 is typically associated with cell cycle arrest and differentiation.

Role in Cancer

E2F4 has been implicated in various types of cancer. It is often found to be overexpressed in lung cancer, breast cancer, and colorectal cancer. The overexpression of E2F4 can lead to uncontrolled cell proliferation, a hallmark of cancer. However, the exact role of E2F4 in cancer progression and its potential as a therapeutic target are still under investigation.

Clinical Significance

Due to its role in cell cycle regulation and cancer, E2F4 is a potential target for cancer therapy. Inhibiting the activity of E2F4 could potentially halt the progression of the cell cycle, thereby inhibiting tumor growth. However, more research is needed to fully understand the potential of E2F4 as a therapeutic target.

See Also

• E2F
• Cell cycle
• Cancer