E4F1
E4F1 is a protein that in humans is encoded by the E4F1 gene. The E4F1 protein is a key regulator of cell cycle progression and apoptosis, and plays a significant role in tumor suppression.
Function[edit | edit source]
The E4F1 protein is a transcription factor involved in the regulation of cell proliferation. It is also implicated in the control of the G1/S transition of the cell cycle. The E4F1 protein has been shown to interact with p53, a protein known for its critical role in preventing cancer.
Clinical significance[edit | edit source]
Alterations in the E4F1 gene have been associated with various types of cancer, including breast cancer and lung cancer. The E4F1 protein is considered a potential target for cancer therapy due to its role in cell cycle regulation and apoptosis.
Research[edit | edit source]
Research on the E4F1 protein has focused on its role in cell cycle regulation and its potential as a target for cancer therapy. Studies have shown that E4F1 is essential for embryonic development and that its absence can lead to embryonic lethality.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
