ELF1

ELF1 (E74 Like ETS Transcription Factor 1) is a protein that in humans is encoded by the ELF1 gene. This protein is a member of the ETS family of transcription factors and plays a crucial role in regulating gene expression. It is involved in various biological processes, including cell growth, cell differentiation, and apoptosis.

Function

ELF1 is a transcription factor that binds to purine-rich DNA sequences. It can form a ternary complex with the serum response factor and the serum response element, thereby playing a role in the regulation of gene activity in response to serum and growth factors. ELF1 is known to regulate several genes, including those involved in the immune response, cell cycle regulation, and apoptosis.

Clinical Significance

Alterations in the ELF1 gene have been associated with various diseases. For example, mutations in this gene have been linked to leukemia, lymphoma, and other types of cancer. In addition, ELF1 has been implicated in autoimmune diseases such as rheumatoid arthritis and lupus.

Structure

The ELF1 protein is composed of 619 amino acids and has a molecular weight of approximately 68 kDa. It contains a DNA-binding domain, a transactivation domain, and a PNT (pointed) domain, which is involved in protein-protein interactions.

Interactions

ELF1 has been shown to interact with a number of other proteins, including SPI1, STAT3, and HDAC1. These interactions play a role in the regulation of gene expression and cellular processes.

See Also

• ETS family
• Transcription factor
• Gene expression