STAT3

STAT3 is a gene that encodes a transcription factor in the Signal transducer and activator of transcription (STAT) family. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.

Function

STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

Clinical significance

Mutations in this gene are associated with hyper-IgM immunodeficiency syndrome and Job's syndrome. STAT3 has been shown to be involved in a variety of cancers, and is considered a potential therapeutic target.

See also

• Signal transducer and activator of transcription
• Hyper-IgM syndrome
• Job's syndrome

External links

• STAT3 at WikiMD