EMPA (drug)
EMPA (Ethinylestradiol 3-methyl ether) is a synthetic estrogen that was never marketed. It is a derivative of ethinylestradiol and is related to mestranol, which, in contrast, has been widely used in hormonal contraception.
Chemistry[edit | edit source]
EMPA is a synthetic, steroidal estrogen that is derived from estradiol, the major endogenous estrogen in humans. It is specifically a derivative of ethinylestradiol, which itself is a derivative of estradiol, with a methyl group attached at the 3-position. EMPA is structurally related to mestranol, which is ethinylestradiol with a methoxy group at the 3-position instead of a methyl group.
Pharmacology[edit | edit source]
As a derivative of ethinylestradiol, EMPA is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. However, it has not been studied in detail, and its exact pharmacological properties are not known.
History[edit | edit source]
EMPA was first described in the scientific literature in 1965. It was never marketed for medical use, in contrast to the closely related drug mestranol, which has been widely used in hormonal contraception.
See also[edit | edit source]
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