Ebalzotan
Ebalzotan is a serotonin 5-HT1A receptor agonist that was under development by Eisai Co. for the treatment of anxiety and depression. It reached Phase II clinical trials for these indications but was discontinued.
History[edit | edit source]
Ebalzotan was first developed by the Japanese pharmaceutical company Eisai Co. The drug was designed to act as a serotonin 5-HT1A receptor agonist, a type of drug that has been used in the treatment of various psychiatric and neurological disorders.
Mechanism of Action[edit | edit source]
Ebalzotan works by binding to and activating the 5-HT1A receptors in the brain. These receptors are a type of G protein-coupled receptor that are activated by the neurotransmitter serotonin. By activating these receptors, ebalzotan can increase the levels of serotonin in the brain, which can help to alleviate symptoms of anxiety and depression.
Clinical Trials[edit | edit source]
Ebalzotan underwent Phase II clinical trials for the treatment of anxiety and depression. However, the development of the drug was discontinued for unknown reasons.
See Also[edit | edit source]
- Serotonin
- 5-HT1A receptor
- Eisai Co.
- Anxiety
- Depression
- Phase II clinical trial
- G protein-coupled receptor
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Contributors: Prab R. Tumpati, MD
