Endothelin receptor type B

Endothelin receptor type B (ET_B) is a protein that in humans is encoded by the EDNRB gene. It is one of two main types of endothelin receptors, the other being endothelin receptor type A (ET_A).

Function

ET_B receptors are found in high concentrations in the lung, kidney, skin, heart, and brain. They play a crucial role in maintaining vascular homeostasis by mediating the effects of endothelin-1, a potent vasoconstrictor and pro-inflammatory peptide.

Structure

The ET_B receptor is a G protein-coupled receptor that spans the cell membrane seven times. It is part of the rhodopsin-like receptors family.

Clinical significance

Mutations in the EDNRB gene have been associated with Hirschsprung's disease, a congenital disorder characterized by the absence of neural crest cells in the colon, leading to severe constipation and intestinal obstruction.

See also

• Endothelin receptor
• Endothelin receptor type A
• Endothelin-1
• G protein-coupled receptor
• Hirschsprung's disease

External links

• GeneCards - EDNRB

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian