Endothelin receptor type B
Endothelin receptor type B (ETB) is a protein that in humans is encoded by the EDNRB gene. It is one of two main types of endothelin receptors, the other being endothelin receptor type A (ETA).
Function[edit | edit source]
ETB receptors are found in high concentrations in the lung, kidney, skin, heart, and brain. They play a crucial role in maintaining vascular homeostasis by mediating the effects of endothelin-1, a potent vasoconstrictor and pro-inflammatory peptide.
Structure[edit | edit source]
The ETB receptor is a G protein-coupled receptor that spans the cell membrane seven times. It is part of the rhodopsin-like receptors family.
Clinical significance[edit | edit source]
Mutations in the EDNRB gene have been associated with Hirschsprung's disease, a congenital disorder characterized by the absence of neural crest cells in the colon, leading to severe constipation and intestinal obstruction.
See also[edit | edit source]
- Endothelin receptor
- Endothelin receptor type A
- Endothelin-1
- G protein-coupled receptor
- Hirschsprung's disease
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
