Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)
| Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.10 | ||||||||
| CAS number | 37250-24-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) is an enzyme that plays a crucial role in the fatty acid biosynthesis pathway. This enzyme is responsible for the reduction of enoyl-ACP (acyl-carrier-protein) to acyl-ACP, utilizing NADPH as a cofactor. The reaction it catalyzes is essential for the elongation of the fatty acid chain during the biosynthesis process.
Function[edit | edit source]
The primary function of enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) is to facilitate the reduction of the double bond in enoyl-ACP to form a saturated acyl-ACP. This step is part of the fatty acid synthase system, which is responsible for the production of long-chain fatty acids. The enzyme specifically uses NADPH as a reducing agent, distinguishing it from other types of enoyl-ACP reductases that may use different cofactors.
Mechanism[edit | edit source]
The enzyme operates by binding to the enoyl-ACP substrate and NADPH. The hydride ion from NADPH is transferred to the double bond of the enoyl group, resulting in the formation of a saturated acyl-ACP. This reaction is stereospecific, meaning that the enzyme only catalyzes the reduction of the B-specific enoyl-ACP.
Structure[edit | edit source]
Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) typically consists of a single polypeptide chain. The active site of the enzyme contains residues that are crucial for binding NADPH and the enoyl-ACP substrate. The enzyme's structure is highly conserved across different species, reflecting its essential role in fatty acid biosynthesis.
Biological Importance[edit | edit source]
This enzyme is vital for the synthesis of fatty acids, which are important components of cell membranes, energy storage molecules, and signaling molecules. Inhibition of enoyl-(acyl-carrier-protein) reductase can lead to the disruption of fatty acid biosynthesis, making it a potential target for antibiotics and herbicides.
Related Enzymes[edit | edit source]
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
