IntEnz

IntEnz (Integrated Enzyme Database) is a comprehensive resource that provides detailed information about enzymes, their nomenclature, structure, and catalytic activity. Managed by the European Bioinformatics Institute (EBI), IntEnz is designed to serve as a central platform for researchers and professionals in the fields of biochemistry, molecular biology, and pharmacology.

Overview

IntEnz is structured to offer a detailed classification of enzymes based on the recommendations of the International Union of Biochemistry and Molecular Biology (IUBMB). It includes information on enzyme-catalyzed reactions, enzyme structures, and the nomenclature as per the Enzyme Commission (EC) numbers. This database is crucial for understanding the biochemical pathways and mechanisms in which these enzymes are involved.

Content and Features

The database categorizes enzymes into classes, subclasses, and sub-subclasses based on the type of reaction they catalyze. Each enzyme entry in IntEnz includes:

• The official EC number
• Recommended name and synonyms
• Reaction type and specific reaction catalyzed
• Information on the enzyme's structure, when available
• Links to related protein structures in the Protein Data Bank (PDB)
• Cross-references to other relevant databases such as KEGG, BRENDA, and UniProt

Usage

IntEnz is utilized by researchers for various purposes including:

• Identification and classification of new enzymes
• Study of metabolic pathways and their regulation
• Drug design and discovery, by understanding enzyme inhibition and activation mechanisms
• Educational purposes in academic settings

Access

The database is accessible online through the EBI website, where users can search for enzymes by their EC number, name, or the reaction they catalyze. IntEnz also provides tools for advanced search options, allowing for more specific queries.

Importance in Research

IntEnz plays a vital role in the field of enzymology, as it helps in the systematic study of enzymes, which are crucial for life processes. By providing a centralized and standardized repository of enzyme data, it supports advancements in both basic science and applied biomedical research.

See Also

• Enzyme Commission number
• Bioinformatics
• Metabolic pathway
• Drug discovery