Epidermolytic acanthoma

Epidermolytic acanthoma is a rare, benign skin lesion that is characterized by its distinctive histological features. It was first described in the medical literature in 1982 by Ackerman and Reddy.

Clinical Presentation

Epidermolytic acanthoma typically presents as a solitary, small, asymptomatic papule that can be found anywhere on the body. However, multiple lesions have been reported in some cases. The color of the lesion can vary from skin-colored to brown.

Histopathology

The histopathological examination of epidermolytic acanthoma reveals acanthosis (thickening of the skin) with hyperkeratosis (thickening of the outer layer of the skin) and parakeratosis (abnormal keratinization of the skin). The most distinctive feature is the presence of epidermolytic hyperkeratosis, which is characterized by vacuolar degeneration of the granular layer and coarse keratohyalin granules.

Diagnosis

The diagnosis of epidermolytic acanthoma is made based on the clinical presentation and confirmed by histopathological examination. Other skin conditions that may have similar clinical features but different histopathological findings need to be ruled out. These include seborrheic keratosis, wart, and squamous cell carcinoma.

Treatment

Treatment is not necessary for epidermolytic acanthoma as it is a benign condition. However, if the lesion is bothersome or for cosmetic reasons, it can be removed by cryotherapy, electrocautery, or surgical excision.

See Also

• Acanthoma
• Epidermolytic hyperkeratosis
• Skin lesion
• Histopathology

References

Epidermolytic acanthoma Resources
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