Epirubicin

Epirubicin is an anthracycline drug used for chemotherapy. It can be used in combination with other medications to treat various types of cancer, including breast cancer, ovarian cancer, gastric cancer, and lung cancer. Epirubicin works by interfering with the growth and spread of cancer cells in the body.

Mechanism of Action[edit | edit source]

Epirubicin is a DNA intercalating agent, meaning it inserts itself between the two strands of the DNA double helix. This prevents the DNA from being properly replicated, which in turn inhibits the growth and division of cancer cells. Epirubicin also generates free radicals, which can damage DNA and other cellular components.

Side Effects[edit | edit source]

Like all chemotherapy drugs, Epirubicin can cause side effects. These can include nausea, vomiting, hair loss, and fatigue. More serious side effects can include heart damage, low blood cell counts, and an increased risk of infection. Patients receiving Epirubicin are closely monitored to manage these side effects.

History and Development[edit | edit source]

Epirubicin was first synthesized in the 1980s as a derivative of doxorubicin, another anthracycline chemotherapy drug. It was developed with the aim of reducing the cardiotoxic side effects associated with doxorubicin, while maintaining its anti-cancer efficacy.

References[edit | edit source]

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