Epithelioid trophoblastic tumour

From WikiMD's Wellnesspedia


Epithelioid trophoblastic tumor (ETT) is a gestational trophoblastic disease with about 110 case reports in the literature. It is a trophoblastic tumor of neoplastic chorionic type associated with the intermediate trophoblast.

Signs and symptoms[edit | edit source]

  • Vaginal bleeding: The most common presenting symptom is vaginal bleeding, which is associated with mild elevation of serum β hCG (< 2,500 IU/l)
  • Amenorrhea.

[1]

Morphology[edit | edit source]

Gross appearance[edit | edit source]

  • There is deep infiltration of the surrounding structures by cystic hemorrhagic masses or discrete nodules.
  • Necrosis is present with white to tan-brown cut surface with hemorrhage.
  • Ulceration (common finding)
  • Fistula (common finding)

Microscopic appearance[edit | edit source]

  • Nodular, well circumscribed, focal infiltrative at the periphery.
  • Uniform, mononucleate tumor cells are arranged in nests and cords.
  • Tumor nests are associated with osinophilic, fibrillar, hyaline-like material.
  • Extensive necrosis with irregular contours.
  • Calcification (common finding)
  • Metaplastic endocervical or endometrial surface epithelium into squamous-like epithelium.

Locations[edit | edit source]

Common locations are:

  • Uterus
    • Lower uterine segment (40%)
    • Cervix (31% of cases)
  • Lungs (19% of cases)

They may rarely develop in

  • Vagina
  • Broad ligament
  • Fallopian tubes
  • Other pelvic organs

[2]

Diagnosis[edit | edit source]

Treatment[edit | edit source]

Epithelioid trophoblastic tumors (ETTs) are resistant to chemotherapy. Stage I disease is treated with hysterectomy, while metastatic disease is treated with surgery and chemotherapy. [2]

Prognosis[edit | edit source]

Metastasis occur in 25% of cases and 10% die of the disease. Mitotic count of > 6/10HPF is an unfavorable prognostic factor. [2]

References[edit | edit source]

  1. http://www.pathologyoutlines.com/topic/placentaETT.html clinical features
  2. 2.0 2.1 2.2 Epithelioid trophoblastic tumor [1]. Pathology outlines, August 26, 2017.
Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.


Contributors: Prab R. Tumpati, MD