Esomeprazole sodium

Esomeprazole sodium - the sodium salt of the s isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen potassium adenosine triphosphatase (h+/k+ atpase), thereby inhibiting its activity and the parietal cell secretion of h+ ions into the gastric lumen, the final step in gastric acid production. H+/k+ atpase is an integral membrane protein of the gastric parietal cell.

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‎ Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Esomeprazole sodium for any updates.

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