Interstitial nephritis
Interstitial Nephritis[edit | edit source]
Introduction[edit | edit source]
Interstitial Nephritis, also known as tubulointerstitial nephritis, is a renal condition characterized by inflammation of the renal interstitium. The renal interstitium is a key component of kidney tissue, surrounding the renal tubules.
Renal Interstitium Anatomy[edit | edit source]
The renal interstitium comprises a collection of cells, extracellular matrix, and fluid, providing structural support to the renal tubules. It plays a crucial role in fluid and electrolyte exchange, as well as the endocrine functions of the kidney.
Causes and Types[edit | edit source]
Interstitial nephritis can be acute or chronic and is caused by a variety of factors, including:
- Allergic reactions to medications (e.g., antibiotics, NSAIDs)
- Infections
- Autoimmune disorders
- Toxins
Pathophysiology[edit | edit source]
The condition involves inflammation that leads to damage or destruction of the tubules and interstitial tissue. This can disrupt normal kidney function and lead to renal failure if not properly managed.
Symptoms[edit | edit source]
Symptoms of interstitial nephritis may include:
- Kidney pain or tenderness
- Changes in urine output
- Fever
- Rash
- Fatigue
Diagnosis[edit | edit source]
Diagnosis typically involves:
- Laboratory tests (urinalysis, blood tests)
- Imaging studies (ultrasound, CT scan)
- Renal biopsy for definitive diagnosis
Treatment[edit | edit source]
Treatment depends on the underlying cause and may include:
- Cessation of offending drugs
- Corticosteroids or other immunosuppressive drugs
- Treatment of underlying infections or autoimmune diseases
- Dialysis in cases of severe renal impairment
Prognosis[edit | edit source]
The prognosis varies based on the cause and severity. Acute interstitial nephritis may be reversible with timely treatment, while chronic forms can lead to permanent kidney damage.
Epidemiology[edit | edit source]
Interstitial nephritis accounts for a significant portion of acute kidney injuries, with varying prevalence depending on the population and underlying causes.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
| Interstitial nephritis Resources | |
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