Estradiol/norethisterone

Estradiol/norethisterone is a hormone replacement therapy (HRT) medication that combines two active ingredients: estradiol, a form of the female sex hormone estrogen, and norethisterone, a synthetic form of the female sex hormone progesterone. This combination is used to alleviate symptoms of menopause in women, such as hot flashes, night sweats, mood swings, and vaginal dryness.

Composition and Formulation

Estradiol/norethisterone is available in tablet form. Each tablet contains a certain amount of estradiol and norethisterone. The exact dosage varies depending on the specific formulation and the needs of the individual patient.

Mechanism of Action

Estradiol/norethisterone works by replacing the declining levels of estrogen and progesterone in the body during menopause. Estradiol, the form of estrogen used in this medication, helps to regulate the menstrual cycle and maintain the health of the reproductive system. Norethisterone, a synthetic form of progesterone, helps to regulate the menstrual cycle and maintain the health of the uterus.

Uses

Estradiol/norethisterone is primarily used to treat symptoms of menopause in women who have not had a hysterectomy. It can also be used to prevent osteoporosis in postmenopausal women who are at high risk of fractures.

Side Effects

Like all medications, estradiol/norethisterone can cause side effects. Common side effects include headaches, breast tenderness, nausea, and mood changes. More serious side effects can include blood clots, stroke, and an increased risk of certain types of cancer.

Precautions

Before starting estradiol/norethisterone, patients should discuss their medical history with their doctor, especially any history of blood clots, stroke, heart disease, liver disease, or certain types of cancer. This medication should not be used during pregnancy or breastfeeding.

See Also

• Hormone replacement therapy
• Menopause
• Estrogen
• Progesterone