Estradiol 17β-benzoate

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Estradiol 17β-benzoate is a synthetic ester of the natural estrogen, estradiol. It is used in various medical applications, particularly in hormone replacement therapy and in veterinary medicine.

Chemical Structure and Properties

Estradiol 17β-benzoate is an estradiol molecule esterified at the 17β position with a benzoate group. This modification increases the lipophilicity of the molecule, allowing for a slower release and longer duration of action when administered.

Medical Uses

Estradiol 17β-benzoate is primarily used in hormone replacement therapy (HRT) for the treatment of symptoms associated with menopause, such as hot flashes, vaginal atrophy, and osteoporosis. It is also used in the treatment of hypogonadism in women and as part of feminizing hormone therapy for transgender women.

In veterinary medicine, estradiol 17β-benzoate is used to manage reproductive issues in livestock, such as inducing estrus in cattle.

Pharmacokinetics

The esterification of estradiol with a benzoate group results in a compound that is more slowly absorbed when administered intramuscularly. This leads to a prolonged duration of action compared to unmodified estradiol. Once in the bloodstream, estradiol 17β-benzoate is hydrolyzed to release free estradiol, which then exerts its physiological effects.

Side Effects

As with other estrogen therapies, the use of estradiol 17β-benzoate can be associated with side effects such as nausea, breast tenderness, headache, and an increased risk of thromboembolic events. Long-term use may also be associated with an increased risk of endometrial cancer and breast cancer.

See Also

• Estradiol
• Hormone replacement therapy
• Menopause
• Hypogonadism
• Feminizing hormone therapy
• Transgender