Estradiol 17β-benzoate

Estradiol 17β-benzoate is a synthetic, steroidal estrogen that is a derivative of estradiol. It is specifically, the 17β-benzoate ester of estradiol. Estradiol 17β-benzoate was introduced for medical use in the 1930s.

Pharmacology

Estradiol 17β-benzoate is a synthetic estrane steroid and a derivative of estradiol. It is an estrogen ester; specifically, it is the 17β-benzoate ester of estradiol. The pharmacology of estradiol 17β-benzoate is similar to that of estradiol, the major endogenous estrogen in humans.

Medical uses

Estradiol 17β-benzoate is used in hormone therapy for menopausal symptoms and low estrogen levels, and in hormonal contraception. It is also used in veterinary medicine.

Side effects

Like other estrogens, estradiol 17β-benzoate can have a variety of side effects, including nausea, bloating, breast tenderness, and an increased risk of thrombosis.

Pharmacokinetics

After administration, estradiol 17β-benzoate is stored in the body and slowly released over a period of several days. It is metabolized in the liver by hydrolysis into estradiol and benzoic acid.

See also

• List of estrogen esters
• Estradiol benzoate
• Estradiol valerate

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