Estradiol dibutyrate

Estradiol dibutyrate (EDB) is a synthetic, steroidal estrogen that is used in medicine. It is an ester of estradiol, a naturally occurring estrogen, and butyric acid, a short-chain fatty acid. EDB is used in hormone therapy for menopausal symptoms and in hormonal birth control.

Pharmacology

EDB acts as a prodrug to estradiol in the body. After administration, it is converted into estradiol by esterases. Estradiol is a potent estrogen and is responsible for the effects of EDB. It binds to and activates the estrogen receptor, a nuclear receptor that is expressed in many different tissues in the body.

Medical uses

EDB is used in hormone therapy for menopausal symptoms such as hot flashes, vaginal dryness, and osteoporosis. It is also used in hormonal birth control, in combination with a progestin. EDB has been used in the treatment of breast cancer, although it is not commonly used for this purpose today due to the availability of more effective treatments.

Side effects

The side effects of EDB are similar to those of other estrogens. They can include breast tenderness, nausea, bloating, and an increased risk of blood clots and stroke. Long-term use of EDB can increase the risk of endometrial cancer.

History

EDB was first synthesized in the 1950s. It was introduced for medical use in the 1960s.

Society and culture

EDB is marketed under a variety of brand names worldwide. It is available as an oral tablet, a transdermal patch, and a vaginal ring.

See also

• List of estrogens
• Estradiol
• Estrogen receptor
• Hormone therapy
• Hormonal birth control