Estradiol dienantate

Estradiol dienanthate (ED), also known as estradiol dienantate, is a synthetic, steroidal estrogen and an estrogen ester. It is an ester of estradiol, the primary female sex hormone. ED is used in hormone therapy for menopausal symptoms and low estrogen levels in women. It is also used in the treatment of breast cancer and prostate cancer.

Pharmacology

ED is a prodrug of estradiol, meaning it is metabolized in the body to produce estradiol. This process occurs in the liver, where the dienanthate ester is cleaved off, releasing estradiol. The estradiol then binds to and activates the estrogen receptor, exerting its effects in the body.

Medical uses

ED is used in hormone therapy for menopausal symptoms such as hot flashes, vaginal dryness, and mood swings. It is also used to treat low estrogen levels in women due to conditions such as hypogonadism or ovarian failure. In addition, ED is used in the treatment of certain types of breast cancer in women and prostate cancer in men.

Side effects

Like all estrogens, ED can have a number of side effects. These can include nausea, bloating, breast tenderness, and an increased risk of blood clots and stroke. Long-term use of ED can also increase the risk of certain types of cancer, including endometrial cancer and breast cancer.

See also

• Estradiol
• Estrogen
• Estrogen receptor
• Hormone therapy
• Menopause
• Breast cancer
• Prostate cancer