Estrogen-related receptor beta

Estrogen-related receptor beta (ERRβ), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a protein that in humans is encoded by the ESRRB (estrogen-related receptor beta) gene. ERRβ is a member of the nuclear receptor family of intracellular transcription factors.

Function

ERRβ is an orphan receptor, meaning the endogenous ligand has not yet been identified. Despite the name, ERRβ does not bind estrogen or other steroid hormones. However, it is closely related to the estrogen receptor and the two receptors can bind to many of the same DNA sequences (estrogen response elements). ERRβ has been shown to participate in the regulation of placental development and stem cell maintenance.

Clinical significance

Alterations in ERRβ expression have been associated with cancer, particularly breast cancer and prostate cancer. ERRβ has been shown to suppress tumor growth and metastasis in prostate cancer, suggesting it may have a protective role. In contrast, high levels of ERRβ expression have been associated with poor prognosis in breast cancer.

See also

• Estrogen receptor
• Nuclear receptor
• Transcription factor

External links

• ESRRB gene details page in the HGNC database.