Ethinylestradiol 3-benzoate
Ethinylestradiol 3-benzoate is a synthetic, steroidal estrogen that is used in hormone replacement therapy and as a component of hormonal contraception. It is a derivative of ethinylestradiol, a potent synthetic estrogen, with a benzoate ester added at the 3-position. This modification enhances the drug's lipid solubility, allowing it to be administered via intramuscular injection.
Pharmacology[edit | edit source]
Ethinylestradiol 3-benzoate acts as an agonist of the estrogen receptor, a nuclear receptor that is activated by the hormone estrogen. Upon binding to the receptor, ethinylestradiol 3-benzoate induces a conformational change that allows the receptor to bind to specific DNA sequences known as estrogen response elements. This binding regulates the transcription of various genes, leading to the physiological effects of estrogen.
Clinical Use[edit | edit source]
Ethinylestradiol 3-benzoate is used in hormone replacement therapy to treat symptoms of menopause, such as hot flashes and vaginal dryness. It is also used in hormonal contraception to prevent ovulation and pregnancy. In addition, it may be used to treat certain conditions that are caused by low estrogen levels, such as osteoporosis and hypoestrogenism.
Side Effects[edit | edit source]
Like other estrogens, ethinylestradiol 3-benzoate can cause a number of side effects, including nausea, bloating, breast tenderness, and an increased risk of blood clots. Long-term use can also increase the risk of certain types of cancer, including breast cancer and endometrial cancer.
See Also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
