Ethinylestradiol benzoate
Ethinylestradiol benzoate is a synthetic, steroidal estrogen that is derived from estradiol. It is a long-acting estrogen, and is an estrogen ester, specifically, the 3-benzoate ester of ethinylestradiol. Ethinylestradiol benzoate is used in medicine for hormone therapy.
Pharmacology[edit | edit source]
As a form of estrogen, ethinylestradiol benzoate binds to and activates the estrogen receptor, a type of nuclear receptor that is activated by the hormone estrogen. This results in changes in gene expression which can lead to a variety of effects, including the development of female secondary sexual characteristics and the regulation of the menstrual cycle.
Medical uses[edit | edit source]
Ethinylestradiol benzoate is used in hormone therapy for menopausal symptoms, hypogonadism, prostate cancer, and for other conditions. It is also used in hormonal contraception, specifically in combination with a progestogen.
Side effects[edit | edit source]
Like all estrogens, ethinylestradiol benzoate has a number of potential side effects. These can include nausea, breast tenderness, fluid retention, and an increased risk of thrombosis. It can also cause changes in mood and libido.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
