Etofibrate

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Etofibrate
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Etofibrate is a fibrate class medication primarily used to treat hyperlipidemia, which is an elevated level of lipids in the blood. It is a prodrug that is metabolized in the body to clofibric acid and nicotinic acid, both of which contribute to its lipid-lowering effects.

Mechanism of Action[edit | edit source]

Etofibrate works by activating peroxisome proliferator-activated receptor alpha (PPARα), which leads to an increase in the oxidation of fatty acids and a reduction in the production of triglycerides. This results in a decrease in very-low-density lipoprotein (VLDL) and an increase in high-density lipoprotein (HDL) levels.

Indications[edit | edit source]

Etofibrate is indicated for the treatment of various types of hyperlipidemia, including:

Pharmacokinetics[edit | edit source]

After oral administration, etofibrate is hydrolyzed to its active metabolites, clofibric acid and nicotinic acid. These metabolites are then absorbed into the bloodstream and exert their lipid-lowering effects. The drug is primarily excreted through the kidneys.

Side Effects[edit | edit source]

Common side effects of etofibrate include:

Contraindications[edit | edit source]

Etofibrate is contraindicated in patients with:

Drug Interactions[edit | edit source]

Etofibrate may interact with other medications, including:

See Also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD