Etofibrate
Etofibrate is a fibrate class medication primarily used to treat hyperlipidemia, which is an elevated level of lipids in the blood. It is a prodrug that is metabolized in the body to clofibric acid and nicotinic acid, both of which contribute to its lipid-lowering effects.
Mechanism of Action[edit | edit source]
Etofibrate works by activating peroxisome proliferator-activated receptor alpha (PPARα), which leads to an increase in the oxidation of fatty acids and a reduction in the production of triglycerides. This results in a decrease in very-low-density lipoprotein (VLDL) and an increase in high-density lipoprotein (HDL) levels.
Indications[edit | edit source]
Etofibrate is indicated for the treatment of various types of hyperlipidemia, including:
- Hypercholesterolemia
- Hypertriglyceridemia
- Mixed dyslipidemia
Pharmacokinetics[edit | edit source]
After oral administration, etofibrate is hydrolyzed to its active metabolites, clofibric acid and nicotinic acid. These metabolites are then absorbed into the bloodstream and exert their lipid-lowering effects. The drug is primarily excreted through the kidneys.
Side Effects[edit | edit source]
Common side effects of etofibrate include:
Contraindications[edit | edit source]
Etofibrate is contraindicated in patients with:
- Severe liver disease
- Severe kidney disease
- Gallbladder disease
- Known hypersensitivity to fibrates
Drug Interactions[edit | edit source]
Etofibrate may interact with other medications, including:
- Anticoagulants: Increased risk of bleeding
- Statins: Increased risk of myopathy and rhabdomyolysis
See Also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD