Ochronosis
(Redirected from Exogenous ochronosis)
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
Ochronosis | |
---|---|
Synonyms | N/A |
Pronounce | N/A |
Specialty | N/A |
Symptoms | Darkening of the skin, arthritis, heart valve disease |
Complications | Joint destruction, cardiovascular complications |
Onset | Typically in adulthood |
Duration | Chronic |
Types | N/A |
Causes | Alkaptonuria, exposure to certain chemicals |
Risks | Genetic predisposition, exposure to phenol or hydroquinone |
Diagnosis | Clinical evaluation, urine test for homogentisic acid |
Differential diagnosis | Melanosis, hemochromatosis, argyria |
Prevention | N/A |
Treatment | Vitamin C, dietary restriction of phenylalanine and tyrosine, joint replacement surgery |
Medication | N/A |
Prognosis | Variable, depends on severity and management |
Frequency | Rare |
Deaths | N/A |
Ochronosis is a metabolic disorder characterized by the accumulation of homogentisic acid in connective tissues. It is a rare condition, often associated with Alkaptonuria, a metabolic disorder that affects the body's ability to break down certain amino acids.
Symptoms[edit | edit source]
The most common symptom of Ochronosis is darkening of the skin, particularly in areas exposed to the sun. Other symptoms may include arthritis, heart disease, and kidney stones. The severity of symptoms can vary widely among individuals with the condition.
Causes[edit | edit source]
Ochronosis is caused by a deficiency in the enzyme homogentisate 1,2-dioxygenase, which is involved in the breakdown of the amino acids phenylalanine and tyrosine. This deficiency leads to the accumulation of homogentisic acid in the body, which can cause damage to connective tissues.
Diagnosis[edit | edit source]
Diagnosis of Ochronosis is typically based on the presence of characteristic symptoms, such as darkening of the skin and arthritis. Laboratory tests can also be used to measure the levels of homogentisic acid in the urine.
Treatment[edit | edit source]
There is currently no cure for Ochronosis, but treatment can help manage symptoms. This may include pain management for arthritis and lifestyle changes to prevent kidney stones.
See also[edit | edit source]
Transform your life with W8MD's budget GLP1 injections from $125 and up biweekly
W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.
Why choose W8MD?
- Comprehensive care with FDA-approved weight loss medications including:
- loss injections in NYC both generic and brand names:
- weight loss medications including Phentermine, Qsymia, Contrave, Diethylpropion etc.
- Accept most insurances for visits or discounted self pay cost.
- Generic weight loss injections starting from just $125.00 for the starting dose
- In person weight loss NYC and telemedicine medical weight loss options in New York city available
Book Your Appointment
Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia and visit Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD