FITM2

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FITM2 (Fatty Acid Transporter, Member 2) is a protein that in humans is encoded by the FITM2 gene. This protein is involved in the transport of fatty acids across cell membranes, playing a crucial role in lipid metabolism and energy homeostasis.

Function

FITM2 is primarily responsible for the uptake and intracellular transport of long-chain fatty acids. It is an integral membrane protein that facilitates the movement of fatty acids from the extracellular environment into the cell, where they can be utilized for various metabolic processes, including energy production and the synthesis of complex lipids.

Structure

FITM2 is a member of the FIT (Fatty Acid Transporter) family, which is characterized by specific structural motifs that enable the binding and transport of fatty acids. The protein typically spans the cell membrane multiple times, creating a channel through which fatty acids can pass.

Expression

The expression of FITM2 is regulated by various factors, including dietary intake and hormonal signals. It is predominantly expressed in tissues with high rates of fatty acid metabolism, such as the liver, adipose tissue, and muscle.

Clinical Significance

Mutations or dysregulation of the FITM2 gene can lead to metabolic disorders. For instance, impaired function of FITM2 has been associated with conditions such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Understanding the role of FITM2 in these diseases could provide insights into potential therapeutic targets.

Research

Ongoing research is focused on elucidating the detailed mechanisms by which FITM2 transports fatty acids and how its activity is regulated. Studies are also exploring the potential of modulating FITM2 function to treat metabolic diseases.

See Also

• Fatty acid metabolism
• Lipid metabolism
• Membrane transport proteins
• Obesity
• Type 2 diabetes
• Non-alcoholic fatty liver disease