FSH-receptor

FSH-receptor‏‎ (Follicle-stimulating hormone receptor) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH). This receptor is crucial in sexual reproduction and the functioning of the gonads in both males and females.

Structure

The FSH-receptor is a G protein-coupled receptor. This means it is a large protein that crosses the cell membrane seven times. The outside part of the receptor interacts with FSH, and the inside part initiates the first step in a series of chemical reactions inside the cell.

Function

The primary function of the FSH-receptor is to mediate the effects of FSH, which is produced by the pituitary gland. In females, FSH stimulates the growth and maturation of ovarian follicles. In males, FSH stimulates Sertoli cells, which support the development of sperm.

Clinical significance

Mutations in the FSH-receptor can lead to reproductive disorders. For example, inactivating mutations can cause ovarian failure in women and infertility in men. Activating mutations can lead to spontaneous ovulation in women and increased sperm production in men.

Research

Research on the FSH-receptor is ongoing, with scientists seeking to understand its exact structure, how it interacts with FSH, and how mutations in the receptor can lead to disease. This research could lead to new treatments for reproductive disorders.

See also

• Follicle-stimulating hormone
• Gonad
• Ovarian follicle
• Sertoli cell
• Ovarian failure
• Infertility