FSHR

FSHR (Follicle-stimulating hormone receptor) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH). The receptor is expressed on the surface of the ovarian granulosa cells and is involved in ovulation and menstrual cycle regulation.

Structure

The FSHR is a G protein-coupled receptor. It is composed of a large extracellular domain, a seven-transmembrane domain, and an intracellular domain. The extracellular domain is responsible for binding to FSH, while the transmembrane domain is involved in signal transduction.

Function

The primary function of the FSHR is to mediate the actions of FSH. When FSH binds to the receptor, it activates the adenylate cyclase-cAMP pathway, leading to the production of cyclic AMP (cAMP). This, in turn, activates protein kinase A, which phosphorylates various proteins and leads to the activation of multiple signaling pathways.

Clinical significance

Mutations in the FSHR gene can lead to various reproductive disorders. For example, inactivating mutations can cause ovarian failure and infertility, while activating mutations can lead to ovarian hyperstimulation syndrome.

See also

• Follicle-stimulating hormone
• G protein-coupled receptor
• Ovarian hyperstimulation syndrome

References

FSHR Resources
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