Fibroblast growth factor 21

Fibroblast growth factor 21 (FGF21) is a hormone that is part of the fibroblast growth factor family. It is primarily produced in the liver, but can also be found in other tissues such as fat and muscle. FGF21 plays a crucial role in the regulation of metabolism, glucose homeostasis, and insulin sensitivity.

Function

FGF21 is a potent regulator of glucose and lipid metabolism. It is released in response to starvation or ketosis, and acts to increase insulin sensitivity, promote gluconeogenesis, and stimulate lipolysis. FGF21 also has effects on energy expenditure, body weight, and food intake, making it a potential target for the treatment of obesity and type 2 diabetes.

Clinical significance

Studies have shown that FGF21 levels are elevated in individuals with obesity and type 2 diabetes, suggesting a potential role for this hormone in these conditions. Furthermore, administration of FGF21 has been shown to improve insulin resistance, reduce body weight, and improve lipid profile in animal models. These findings have led to the development of FGF21 analogs for the potential treatment of metabolic disorders.

Research

Research into the role of FGF21 in metabolism and disease is ongoing. Current areas of interest include the potential use of FGF21 as a therapeutic target for the treatment of metabolic syndrome, type 2 diabetes, and non-alcoholic fatty liver disease.

See also

• Fibroblast growth factor
• Metabolic syndrome
• Type 2 diabetes
• Non-alcoholic fatty liver disease