Fidarestat

From WikiMD's Wellnesspedia

Fidarestat‏‎ is an aldose reductase inhibitor (ARI) that is primarily used in the treatment of diabetic neuropathy. It is a synthetic drug that was developed in Japan and has been studied extensively for its potential benefits in managing the symptoms of diabetic neuropathy.

Mechanism of Action[edit | edit source]

Fidarestat‏‎ works by inhibiting the enzyme aldose reductase, which is involved in the conversion of glucose to sorbitol. This process is part of the polyol pathway, a metabolic pathway that is believed to play a significant role in the development of diabetic complications. By inhibiting aldose reductase, Fidarestat‏‎ can help to prevent the accumulation of sorbitol and reduce the risk of nerve damage.

Clinical Trials[edit | edit source]

Several clinical trials have been conducted to evaluate the safety and efficacy of Fidarestat‏‎. These trials have generally found that the drug is well-tolerated and can help to improve symptoms of diabetic neuropathy, such as pain and numbness in the extremities.

Side Effects[edit | edit source]

Like all medications, Fidarestat‏‎ can cause side effects. The most common side effects reported in clinical trials include nausea, dizziness, and headache. However, these side effects are generally mild and tend to resolve on their own with continued use of the medication.

Availability[edit | edit source]

Fidarestat‏‎ is not currently approved for use in all countries. It is primarily available in Japan, where it has been approved for the treatment of diabetic neuropathy.

See Also[edit | edit source]

Resources[edit source]

Latest articles - Fidarestat

PubMed
Clinical trials
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AI tools[edit source]

Generative AI tools and links to learn more on Fidarestat: ChatGPT - Bing Chat - Google Gemini. (caution advised).


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Contributors: Prab R. Tumpati, MD