Filtration fraction
Filtration Fraction is a term used in Nephrology to describe the proportion of the renal plasma flow that is filtered by the kidney. It is a key concept in understanding the function of the kidney and its role in maintaining homeostasis in the body.
Definition[edit | edit source]
The Filtration Fraction (FF) is defined as the ratio of the Glomerular Filtration Rate (GFR) to the Renal Plasma Flow (RPF). It is usually expressed as a percentage and typically ranges from 15% to 20% in a healthy individual.
Formula[edit | edit source]
The formula for calculating the Filtration Fraction is:
FF = GFR / RPF
Where:
- GFR is the Glomerular Filtration Rate, which measures the amount of blood filtered by the glomeruli per minute.
- RPF is the Renal Plasma Flow, which measures the volume of plasma that reaches the kidneys per minute.
Clinical Significance[edit | edit source]
The Filtration Fraction is an important parameter in assessing kidney function. Changes in the Filtration Fraction can indicate various kidney diseases and conditions. For example, a decreased Filtration Fraction may indicate glomerulonephritis, while an increased Filtration Fraction may suggest renal artery stenosis.
See Also[edit | edit source]
References[edit | edit source]
- Smith, H.W. (1951). The Kidney: Structure and Function in Health and Disease. Oxford University Press, New York.
- Brenner, B.M., Rector, F.C. (2008). Brenner and Rector's The Kidney, 8th ed. Saunders Elsevier, Philadelphia.
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