Fluprednidene acetate

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A synthetic glucocorticoid corticosteroid


Fluprednidene acetate
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Fluprednidene acetate is a synthetic glucocorticoid corticosteroid used in the treatment of various inflammatory and allergic conditions. It is known for its potent anti-inflammatory properties and is often used in dermatological applications.

Pharmacology[edit | edit source]

Fluprednidene acetate is a corticosteroid, which means it mimics the effects of cortisol, a hormone naturally produced by the adrenal glands. It works by suppressing the immune system and reducing inflammation. This makes it effective in treating conditions such as eczema, psoriasis, and other inflammatory skin disorders.

Mechanism of Action[edit | edit source]

The primary mechanism of action of fluprednidene acetate involves the inhibition of phospholipase A2, an enzyme responsible for the release of arachidonic acid from phospholipids. This inhibition leads to a decrease in the production of prostaglandins and leukotrienes, which are mediators of inflammation. Additionally, fluprednidene acetate induces the production of lipocortins, proteins that further inhibit phospholipase A2 activity.

Clinical Uses[edit | edit source]

Fluprednidene acetate is primarily used in the treatment of:

It is typically applied topically in the form of creams or ointments. The potency of fluprednidene acetate makes it suitable for short-term use in severe cases of skin inflammation.

Side Effects[edit | edit source]

As with other corticosteroids, fluprednidene acetate can cause side effects, especially with prolonged use. Common side effects include:

Systemic absorption can occur, leading to more serious side effects such as adrenal suppression, especially if used over large areas of the body or under occlusive dressings.

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