Fructosamine-3-kinase

Fructosamine-3-kinase (FN3K) is an enzyme that in humans is encoded by the FN3K gene. This enzyme plays a crucial role in the metabolism of fructosamine, a compound formed by a non-enzymatic reaction between glucose and proteins.

Function

Fructosamine-3-kinase catalyzes the phosphorylation of fructosamine to 3-phospho-fructosamine, which is then cleaved by water to yield 3-deoxyglucosone and the original protein. This process is part of the Maillard reaction, a series of reactions between amino acids and reducing sugars that contribute to the browning of foods and the aging of proteins in the body.

Clinical significance

The activity of fructosamine-3-kinase has been linked to the development of diabetes and its complications. High levels of fructosamine are associated with poor glucose control, and the activity of FN3K may help to reduce the accumulation of these compounds. In addition, FN3K may play a role in the development of atherosclerosis and other vascular complications of diabetes.

Structure

The FN3K gene is located on the short (p) arm of chromosome 17 at position 25.3. The encoded protein is 309 amino acids long and has a molecular weight of approximately 35 kDa.

See also

• Fructosamine
• Maillard reaction
• Diabetes