GFRα2

GFRα2 (GDNF family receptor alpha 2) is a protein that in humans is encoded by the GFRA2 gene. It is a member of the GDNF receptor family. It is a cell surface receptor for both GDNF (glial cell line-derived neurotrophic factor) and NTN (neurturin).

Function

GFRα2 is a receptor for neurotrophic factors. Neurotrophic factors are a family of proteins that are responsible for the growth and survival of neurons during development, and for the maintenance of adult nervous systems. GFRα2, along with other receptors in the GDNF family, play key roles in the control of neuron survival and differentiation.

Clinical significance

Mutations in the GFRA2 gene have been associated with Hirschsprung disease, a disorder that affects the large intestine and causes problems with passing stool.

See also

• GDNF family of ligands
• Neurturin
• Hirschsprung's disease

References

GFRα2 Resources
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