GLP-1

GLP-1 or Glucagon-like peptide-1 is a hormone that is synthesized and released by the intestinal cells. It is known to play a significant role in the regulation of blood glucose levels, particularly after meals. GLP-1 is also involved in several other physiological processes, including the regulation of appetite and body weight.

Physiology

GLP-1 is synthesized and released by the L cells of the small intestine and colon in response to food intake. It acts on the pancreas to stimulate insulin secretion and inhibit glucagon secretion, thereby helping to regulate blood glucose levels. GLP-1 also slows gastric emptying and reduces appetite, which can contribute to weight loss.

Role in Diabetes Management

GLP-1 is a target for the treatment of type 2 diabetes. GLP-1 receptor agonists are a class of drugs that mimic the effects of GLP-1 and are used to improve blood glucose control in people with type 2 diabetes. These drugs can also promote weight loss, which can be beneficial for people with type 2 diabetes who are overweight or obese.

Side Effects and Risks

While GLP-1 receptor agonists can be effective for managing blood glucose levels and promoting weight loss, they can also have side effects. These can include nausea, vomiting, and diarrhea. There is also some evidence that these drugs may increase the risk of pancreatitis, although this is still a topic of ongoing research.

See Also

• Type 2 diabetes
• Insulin
• Glucagon
• Pancreas

References

GLP-1 Resources
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