GR-127935

GR-127935 is a drug used in scientific research, which acts as a selective antagonist at the serotonin 5-HT1B and 5-HT1D receptors. It is primarily used in the study of migraine headaches and the role of serotonin in the brain.

Chemistry

GR-127935 is a tryptamine derivative, and its full chemical name is N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1-1'-biphenyl-4-carboxamide. It is a white crystalline solid that is soluble in water and organic solvents.

Pharmacology

GR-127935 acts as a potent and selective antagonist for the 5-HT1B and 5-HT1D receptors. These receptors are a type of G protein-coupled receptor that are activated by the neurotransmitter serotonin. By blocking these receptors, GR-127935 can inhibit the action of serotonin in the brain.

Uses

The primary use of GR-127935 is in scientific research, where it is used to study the role of serotonin in the brain and its involvement in conditions such as migraine headaches. It has also been used in studies investigating the role of these receptors in depression, anxiety, and schizophrenia.

Side Effects

As a research chemical, GR-127935 is not intended for human consumption, and therefore its side effects are not well-studied. However, as it acts on the serotonin system, it could potentially cause side effects similar to other drugs that affect this system, such as nausea, dizziness, and changes in mood.

See Also

• 5-HT1B receptor
• 5-HT1D receptor
• Serotonin
• Migraine