G protein-coupled bile acid receptor

G protein-coupled bile acid receptor (also known as GPBAR1, TGR5, or M-BAR) is a protein that in humans is encoded by the GPBAR1 gene. This receptor belongs to the G protein-coupled receptor (GPCR) superfamily, which plays a crucial role in various physiological processes.

Function

The G protein-coupled bile acid receptor is a member of the GPCR family. It is activated by bile acids, which are steroid acids produced during the metabolism of cholesterol. The activation of this receptor stimulates the production of adenylate cyclase, leading to an increase in cyclic adenosine monophosphate (cAMP) levels, which in turn activates a series of intracellular events.

Clinical significance

Alterations in the function or expression of the G protein-coupled bile acid receptor can lead to various health conditions. For instance, it has been implicated in the regulation of glucose homeostasis, energy metabolism, and inflammation. Therefore, it is considered a potential therapeutic target for the treatment of diabetes, obesity, and inflammatory bowel disease.

See also

• G protein-coupled receptor
• Bile acid
• Cholesterol metabolism

References

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