G protein-coupled bile acid receptor
G protein-coupled bile acid receptor (also known as GPBAR1, TGR5, or M-BAR) is a protein that in humans is encoded by the GPBAR1 gene. This receptor belongs to the G protein-coupled receptor (GPCR) superfamily, which plays a crucial role in various physiological processes.
Function[edit | edit source]
The G protein-coupled bile acid receptor is a member of the GPCR family. It is activated by bile acids, which are steroid acids produced during the metabolism of cholesterol. The activation of this receptor stimulates the production of adenylate cyclase, leading to an increase in cyclic adenosine monophosphate (cAMP) levels, which in turn activates a series of intracellular events.
Clinical significance[edit | edit source]
Alterations in the function or expression of the G protein-coupled bile acid receptor can lead to various health conditions. For instance, it has been implicated in the regulation of glucose homeostasis, energy metabolism, and inflammation. Therefore, it is considered a potential therapeutic target for the treatment of diabetes, obesity, and inflammatory bowel disease.
See also[edit | edit source]
References[edit | edit source]
This GPCR-related article is a stub. You can help WikiMD by expanding it.
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
