Galantamine hydrobromide

Galantamine Hydrobromide is a tertiary alkaloid medication used primarily for the treatment of mild to moderate Alzheimer's disease. It is derived from the bulbs and flowers of the snowdrop (Galanthus spp.), daffodil (Narcissus spp.), and other Amaryllidaceae plants.

Pharmacology

Galantamine hydrobromide acts as a cholinesterase inhibitor, increasing the concentration of acetylcholine in the brain. This is achieved by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine. Galantamine also acts on the nicotinic acetylcholine receptors, further enhancing cholinergic function.

Clinical Use

Galantamine hydrobromide is used in the management of Alzheimer's disease and other forms of dementia. It can improve cognitive function, daily living activities, and global clinical state in patients with mild to moderate Alzheimer's disease.

Side Effects

Common side effects of galantamine hydrobromide include nausea, vomiting, diarrhea, dizziness, and headache. Serious side effects may include bradycardia, syncope, QT interval prolongation, and seizures.

Contraindications

Galantamine hydrobromide is contraindicated in patients with hypersensitivity to galantamine or any component of the formulation. It is also contraindicated in patients with severe hepatic impairment or severe renal impairment.

See Also

• Alzheimer's disease
• Cholinesterase inhibitor
• Acetylcholine
• Nicotinic acetylcholine receptors

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