Gastric lipase

Gastric lipase is an enzyme that plays a critical role in the digestive system by facilitating the digestion of fats. Produced by the chief cells in the lining of the stomach, gastric lipase specifically targets triglycerides, breaking them down into monoglycerides and free fatty acids. This process is essential for the efficient absorption of dietary fats in the small intestine.

Unlike other lipases found in the body, such as pancreatic lipase, gastric lipase is unique in its ability to function optimally in the acidic environment of the stomach. It initiates the digestion of fats soon after they enter the stomach, working in conjunction with lingual lipase, which is secreted by the salivary glands and begins the digestion of fats in the mouth.

The activity of gastric lipase accounts for approximately 10-30% of the fat digestion that occurs in the body. Its efficiency is particularly notable in infants, where it plays a significant role due to the undeveloped state of pancreatic function. In adults, while the contribution of gastric lipase to fat digestion is relatively smaller, it remains an important component of the overall digestive process.

Gastric lipase's function is not only limited to the digestion of dietary fats. It also has a role in the absorption of fat-soluble vitamins (such as Vitamins A, D, E, and K) and other essential nutrients. By breaking down fats into more easily absorbable components, gastric lipase ensures that these vital nutrients can be efficiently absorbed by the body.

In certain medical conditions, such as chronic pancreatitis, where the production or activity of pancreatic lipase is impaired, the role of gastric lipase becomes even more critical. It can partially compensate for the reduced fat digestion capacity, highlighting its importance in maintaining nutritional health.

Research into gastric lipase has also opened up potential therapeutic applications. For instance, synthetic forms of the enzyme have been explored as treatments for conditions characterized by fat malabsorption, such as cystic fibrosis and pancreatic insufficiency.

‎