Gene gun

Gene gun or a biolistic particle delivery system, is a device used to deliver DNA into cells. This method is often used by plant scientists to genetically modify plants. The gene gun is also used in biotechnology, medicine, and research to genetically modify other organisms.

History

The gene gun was developed by John C. Sanford, Ed Wolf, and Nelson Allen at Cornell University, and Ted Klein of DuPont during the 1980s. The technology was later sold to Bio-Rad Laboratories.

Function

The gene gun works by coating small particles of gold or tungsten with DNA and then shooting these particles into a group of cells. The particles penetrate the cells and the DNA is integrated into the cells' own DNA. This method is often used to transform plant cells, but can also be used on animal and bacterial cells.

Applications

The gene gun has been used in a variety of applications. It has been used to create genetically modified crops, such as Bt corn and Roundup Ready soybeans. It has also been used in research to study gene function and protein expression in various organisms.

Advantages and Disadvantages

The gene gun method has several advantages. It is a physical method of gene delivery, so it does not require the use of viruses or bacteria. It can also be used to deliver DNA to a wide variety of cell types.

However, the method also has some disadvantages. It can cause damage to the cells, and the integration of the DNA into the cells' own DNA is random, which can lead to unpredictable results.

See Also

• Genetic engineering
• Genetically modified organism
• Genetically modified food
• Genetically modified crops

References

Gene gun Resources
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