Giant-cell fibroma

Giant-cell fibroma is a type of fibroma that is a benign non-neoplastic neoplasm or tumor-like growth in the oral cavity. It is often found on the gingiva or the tongue.

Etiology[edit | edit source]

The exact cause of giant-cell fibroma is unknown. However, it is believed to be a reactive lesion, possibly to trauma or irritation.

Clinical Features[edit | edit source]

Giant-cell fibroma usually presents as a small, painless, firm, and nodular growth. It is typically less than 1 cm in size and has a pink or white color. The surface of the lesion may be smooth or pebbled. It is most commonly found on the gingiva, followed by the tongue, palate, and buccal mucosa.

Histopathology[edit | edit source]

Histologically, giant-cell fibroma is characterized by the presence of large, stellate-shaped fibroblasts with multiple nuclei, known as giant cells. These cells are found in the connective tissue stroma, which is covered by a stratified squamous epithelium. The epithelium may show rete ridges, and the underlying connective tissue often has a dense inflammatory infiltrate.

Diagnosis[edit | edit source]

The diagnosis of giant-cell fibroma is based on clinical and histopathological findings. Other conditions that may resemble giant-cell fibroma clinically include fibrous hyperplasia, neurofibroma, and squamous cell papilloma. Therefore, a biopsy is often necessary to confirm the diagnosis.

Treatment[edit | edit source]

The treatment of choice for giant-cell fibroma is surgical excision. The prognosis is excellent, and recurrence is rare.

See Also[edit | edit source]

Giant-cell fibroma Resources
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